Urea → HCID 178517411, Verbindung
Reaktionsgleichung
[NH2:1][C:2]1[C:9]([Cl:10])=[CH:8][C:7]([Br:11])=[CH:6][C:3]=1[CH:4]=O.[NH2:12][C:13](N)=[O:14]>O>[Br:11][C:7]1[CH:6]=[C:3]2[C:2](=[C:9]([Cl:10])[CH:8]=1)[N:1]=[C:13]([OH:14])[N:12]=[CH:4]2Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 180 °C
Versuchsvorschrift
A mixture of 2-amino-5-bromo-3-chlorobenzaldehyde (9.0 g, 38.6 mmol) and urea (34.7 g, 579 mmol) was heated to 180° C. and stirred for 2 hours. The reaction mixture was cooled to room temperature, and the resulting precipitate was diluted with water (1 L) and stirred for 2 hours. The resulting precipitate was filtered, and the moisture trapped was completely removed by the co-evaporation with toluene three times. The title compound (9.0 g, 90%) was obtained as a yellow solid. MS (ES+) C8H4BrClN2O requires: 257, 259, found: 258, 260 [M+H]+.
Aufarbeitung
- temperatureThe reaction mixture was cooled to room temperature
- stirringstirred for 2 hours
- filtrationThe resulting precipitate was filtered
- customthe moisture trapped was completely removed by the co-evaporation with toluene three times
Quellen und Nachweise
- ORD-Eintrag
- ord-a8ea5ff4c7204ff3b8a8620c76682f34
- Quelldatensatz
- uspto-grants-2016_09
- Patentnummer
- US09434700B2
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