Water → 2-Acetyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (3-methylpyridin-4-yl)amide

HRID 564735Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 564735
[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:12]2[CH:21]=[C:20]([C:22](OC)([O:24]C)[CH3:23])[O:19][C:13]=2[C:14]([O:17][CH3:18])=[N:15][CH:16]=1)=[O:10].FC(F)(F)C(O)=O.O>C(Cl)(Cl)Cl.ClCCl>[CH3:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[NH:8][C:9]([C:11]1[C:12]2[CH:21]=[C:20]([C:22](=[O:24])[CH3:23])[O:19][C:13]=2[C:14]([O:17][CH3:18])=[N:15][CH:16]=1)=[O:10]

Komponenten

6

Edukt 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 700816022-(1,1-Dimethoxyethyl)-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (3-methylpyridin-4-yl)amide

Produkt 1

HCID 867561882-Acetyl-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (3-methylpyridin-4-yl)amideAusbeute 83,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6212ChloroformLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2-(1,1-Dimethoxyethyl)-7-methoxyfuro[2,3-c]pyridine-4-carboxylic acid (3-methylpyridin-4-yl)amide (0.15 g), trifluoroacetic acid (0.23 ml) and water (0.50 ml) were stirred at 50° C. in chloroform (20 ml) for 4 h. The mixture was cooled and diluted with dichloromethane (30 ml), washed with saturated sodium bicarbonate solution (30 ml) then water (30 ml), dried over magnesium sulfate, filtered and the solvent removed in vacuo to give the title compound (0.11 g) as a cream solid.

Aufarbeitung

  1. temperatureThe mixture was cooled
  2. washwashed with saturated sodium bicarbonate solution (30 ml)
  3. dry with materialwater (30 ml), dried over magnesium sulfate
  4. filtrationfiltered
  5. customthe solvent removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0b1df72aa6ac4ecca8134a7d8c70ac35
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06169090A

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