Morpholine → 5-(Morpholine-4-carbonyl)-2-pyridinecarboxylic acid, methyl ester
Reaktionsgleichung
[C:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9](Cl)=[O:10])=[CH:7][N:6]=1)([O:3][CH3:4])=[O:2].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[N:14]1([C:9]([C:8]2[CH:12]=[CH:13][C:5]([C:1]([O:3][CH3:4])=[O:2])=[N:6][CH:7]=2)=[O:10])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1Komponenten
3
Versuchsvorschrift
In step b, the acid chloride 11 is amidated with morpholine 12 by techniques and procedures well known and appreciated by one of ordinary skill in the art to give the corresponding 5-(morpholine-4-carbonyl)-2-pyridinecarboxylic acid, methyl ester 13.
Quellen und Nachweise
- ORD-Eintrag
- ord-87d57140c0e74f01ac3419cf49b777e3
- Quelldatensatz
- uspto-grants-2001_01
- Patentnummer
- US06172044B2
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