Methanol → Methyl 6-Bromohexanoate

Temperatur

25 °C

To a 2 liter round bottomed flask, charged with 99.7 g (0.511 mol) of 6-bromohexanoate (Aldrich Chemical Co., Milwaukee, Wis.) and 1 liter of methanol, was bubbled hydrogen chloride gas for 1-2 minutes. The mixture was stirred at 20-30° C. for 18 h and then concentrated via rotary evaporation. The residue was diluted with 500 mL of diethyl ether and washed with 150 mL of de-ionized water, 200 mL of saturated sodium bicarbonate, and then once again with 200 mL of de-ionized water. The organic phase was dried over anhydrous magnesium sulfate, filtered and concentrated via rotary evaporation. The residue was distilled under vacuum to afford 99.6 g of the product (1) as a colorless oil (93%): b.p.=93-96° C. at 3 mm Hg: 1H NMR (d6-DMSO) d 3.57 (3H, s), 3.51 (2H, t), 2.30 (2H, t), 1.78 (2H, pentet) and 1.62-1.28 (4H, m) ppm.

1. customwas bubbled hydrogen chloride gas for 1-2 minutes
2. concentrationconcentrated via rotary evaporation
3. additionThe residue was diluted with 500 mL of diethyl ether
4. washwashed with 150 mL of de-ionized water, 200 mL of saturated sodium bicarbonate
5. dry with materialThe organic phase was dried over anhydrous magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated via rotary evaporation
8. distillationThe residue was distilled under vacuum

ORD-Eintrag

ord-b992ad473412439ea2523ed23e8a53ac

Quelldatensatz

uspto-grants-2001_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06172045B2