1-(4-Nitrobenzyl)piperidine → 4-(Piperidin-1-ylmethyl)aniline

HRID 565831

Reaktionsgleichung

Reaktionsgleichung von HRID 565831
[N+:1]([C:4]1[CH:16]=[CH:15][C:7]([CH2:8][N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:6][CH:5]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:16]=[CH:15][C:7]([CH2:8][N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:6][CH:5]=1

Komponenten

4

Edukt 1

HCID 7835411-(4-Nitrobenzyl)piperidine

Produkt 1

HCID 8461504-(Piperidin-1-ylmethyl)anilineAusbeute 18,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

In ethanol (50 ml) was dissolved 1-(4-nitrobenzyl)piperidine (6.41 g), and 10% dried palladium on carbon (0.33 g) was added to the mixture. Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 24 hours. The palladium was filtered off, and the filtrate was concentrated. The residue was recrystallized from hexane to give 1-(4-aminobenzyl)piperidine (1.01 g) as pale yellow crystals.

Aufarbeitung

  1. additionwas added to the mixture
  2. filtrationThe palladium was filtered off
  3. concentrationthe filtrate was concentrated
  4. customThe residue was recrystallized from hexane

Quellen und Nachweise

ORD-Eintrag
ord-503b4ff6a8fa4e7798c018ced35f5f00
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06172061B2

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