1-Methyl-4-[(4-nitrobenzyl)sulfonyl]benzene → 4-[[(4-Methylphenyl)sulfonyl]methyl]benzenamine

HRID 565977

Reaktionsgleichung

Reaktionsgleichung von HRID 565977
[N+:1]([C:4]1[CH:20]=[CH:19][C:7]([CH2:8][S:9]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)(=[O:11])=[O:10])=[CH:6][CH:5]=1)([O-])=O>C(O)C.C(OCC)(=O)C.[Pd]>[CH3:18][C:15]1[CH:14]=[CH:13][C:12]([S:9]([CH2:8][C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:20][CH:19]=2)(=[O:11])=[O:10])=[CH:17][CH:16]=1

Komponenten

5

Edukt 1

HCID 8000821-Methyl-4-[(4-nitrobenzyl)sulfonyl]benzene

Produkt 1

HCID 15084184-[[(4-Methylphenyl)sulfonyl]methyl]benzenamineAusbeute 89,2 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

In ethanol (10 ml) and ethyl acetate (60 ml) was dissolved 4-methylphenyl 4-nitrobenzyl sulfone (0.5 g; G. Bram et al., Synthesis, 1987, 56-59). To the mixture was added 10% palladium on carbon (0.05 g) and catalytic hydrogenation was carried out at room temperature over night. The catalyst was filtered off, and the solvent was evaporated to give 4-aminobenzyl 4-methylphenyl sulfone (0.4 g) as colorless crystals.

Aufarbeitung

  1. waitwas carried out at room temperature over night
  2. filtrationThe catalyst was filtered off
  3. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-28f07e2f5e11418885a539f27448c718
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06172061B2

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