Sodium Methoxide → 2-(6-Amino-2-pyridyl)ethanethiol

HRID 566242Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 566242
C([S:4][CH2:5][CH2:6][C:7]1[N:12]=[C:11]([NH2:13])[CH:10]=[CH:9][CH:8]=1)(=O)C.C[O-].[Na+]>CO.Cl>[NH2:13][C:11]1[N:12]=[C:7]([CH2:6][CH2:5][SH:4])[CH:8]=[CH:9][CH:10]=1

Komponenten

5

Edukt 2

HCID 10942334Sodium MethoxideHCID 212658556-(2-Acetylthioethyl)-2-pyridylamine

Produkt 1

HCID 212657842-(6-Amino-2-pyridyl)ethanethiol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 887MethanolLösungsmittel2×

Versuchsvorschrift

6-(2-Acetylthioethyl)-2-pyridylamine (0.56 g) was dissolved in methanol (10 ml). To the solution was added, at 0° C., sodium methylate (a 4.9N methanol solution, 0.58 ml), and the mixture was stirred for 30 minutes. To the reaction mixture was added iN hydrochloric acid (2.85 ml), followed by concentration under reduced pressure. To the concentrate was added ethyl acetate (10 ml), which was subjected to extraction. The extract solution was dried over anhydrous magnesium sulfate, followed by concentration to leave the title compound as an oily product (0.43 g).

Aufarbeitung

  1. additionTo the solution was added, at 0° C.
  2. concentrationfollowed by concentration under reduced pressure
  3. additionTo the concentrate was added ethyl acetate (10 ml), which
  4. extractionwas subjected to extraction
  5. dry with materialThe extract solution was dried over anhydrous magnesium sulfate
  6. concentrationfollowed by concentration

Quellen und Nachweise

ORD-Eintrag
ord-96f7ca40286f450c9f28596ebf21dfb0
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06174877B1

Notizen zur Reaktion

Wird geladen…