tert-Butyl 2-bromopropanoate → tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate

HRID 56627

Reaktionsgleichung

Reaktionsgleichung von HRID 56627
[Br:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[CH:3]=1.Br[CH:10]([CH3:18])[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12]>>[Br:1][C:2]1[CH:7]=[CH:6][N:5]([CH:10]([CH3:18])[C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[C:4](=[O:8])[CH:3]=1

Komponenten

3

Edukt 2

HCID 545327tert-Butyl 2-bromopropanoateHCID 8171154-Bromo-2-hydroxypyridine

Produkt 1

HCID 117622807tert-Butyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)propanoate

Versuchsvorschrift

6.0 g (34.5 mmol) of 4-bromopyridin-2(1H)-one and 7.9 g (37.9 mmol) of tert-butyl 2-bromopropanoate (racemate) were reacted according to General Method 4B. After removal of the DMF, the desired product was precipitated with water and then purified further by flash chromatography (silica gel 60, mobile phase: cyclohexane/ethyl acetate mixtures). Yield: 7.4 g (69% of theory)

Aufarbeitung

  1. customAfter removal of the DMF
  2. customthe desired product was precipitated with water
  3. custompurified further by flash chromatography (silica gel 60, mobile phase: cyclohexane/ethyl acetate mixtures)

Quellen und Nachweise

ORD-Eintrag
ord-a3d9a6c70f324a2bbe12ad35708693af
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434690B2

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