Acetic Anhydride → 6-(5-Methyl-1,3,4-oxadiazol-2-yl)-pyrido[3,4-d]pyrimidin-4-one
Reaktionsgleichung
N1[C:5]([C:6]2[N:16]=[CH:15][C:9]3[N:10]=[CH:11][NH:12][C:13](=[O:14])[C:8]=3[CH:7]=2)=[N:4][N:3]=N1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[CH3:18][C:17]1[O:19][C:5]([C:6]2[N:16]=[CH:15][C:9]3[N:10]=[CH:11][NH:12][C:13](=[O:14])[C:8]=3[CH:7]=2)=[N:4][N:3]=1Komponenten
3
Versuchsvorschrift
6-(1,2,3,4-Tetrazol-5-yl)-pyrido[3,4-d]pyrimidin-4-one (1.4 g) in acetic anhydride (10 ml) was heated at reflux under N2 for 2.5 hours. The cooled mixture was absorbed onto silica and purified by chromatography to give the title compound 90.14 g) as a beige solid; δH [2H6]DMSO 13.0(1H,bs), 9.30 (1H,s), 8.66 (1H,s), 8.47 (1H,s) 2.75 (3H,s); m/z (M+1+)230.
Aufarbeitung
- temperatureat reflux under N2 for 2.5 hours
- customThe cooled mixture was absorbed onto silica
- custompurified by chromatography