Bromine → Ethyl 6-bromo-6-(4-chlorobenzoyl)hexanoate

HRID 567161Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 567161
[Br:1]Br.[Cl:3][C:4]1[CH:21]=[CH:20][C:7]([C:8]([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:9])=[CH:6][CH:5]=1>ClCCl>[Br:1][CH:10]([C:8](=[O:9])[C:7]1[CH:6]=[CH:5][C:4]([Cl:3])=[CH:21][CH:20]=1)[CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 11065929Ethyl 7-(4-chlorophenyl)-7-oxoheptanoate

Produkt 1

HCID 11810554Ethyl 6-bromo-6-(4-chlorobenzoyl)hexanoateAusbeute 99,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Bromine(21.1 g) was added dropwise to a dichloromethane solution (200 ml) of ethyl 6-(4-chlorobenzoyl)hexanoate (37.3 g) at room temperature. After stirring for 30 minutes, the reaction mixture was washed with sodium hydrogensulfite, saturated sodium bicarbonate and water in turn. The dichloromethane layer was dried(MgSO4). The solvent was evaporated to give ethyl 6-bromo-6-(4-chlorobenzoyl)hexanoate(47.6 g, quant.) as an oily substance.

Aufarbeitung

  1. washthe reaction mixture was washed with sodium hydrogensulfite, saturated sodium bicarbonate and water in turn
  2. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-2e54f8f8b18440b08902bdfd8757a7b0
Quelldatensatz
uspto-grants-2001_01
Patentnummer
US06177452B1

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