Hydrochloric Acid → 2-Sulfamoylthieno[3,2-c]pyridin-4(5H)-one

HRID 569060

Reaktionsgleichung

Reaktionsgleichung von HRID 569060
[S:1]([C:5]1[S:13][C:12]2[CH:11]=[CH:10][N:9]=[C:8](Cl)[C:7]=2[CH:6]=1)(=[O:4])(=[O:3])[NH2:2].Cl.[OH-:16].[Na+]>O>[S:1]([C:5]1[S:13][C:12]2[CH:11]=[CH:10][NH:9][C:8](=[O:16])[C:7]=2[CH:6]=1)(=[O:4])(=[O:3])[NH2:2]

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 201485834-Chlorothieno[3,2-c]pyridine-2-sulfonamide

Produkt 1

HCID 201485572-Sulfamoylthieno[3,2-c]pyridin-4(5H)-oneAusbeute 66 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A solution of 2-sulfamoyl-4-chlorothieno[3,2-c]pyridine (0.87 g, 3.5 mmol) in 10 N sodium hydroxide (1.8 ml) diluted with water (7 ml) was heated at 100° C. for 5-10 hours. After cooling the reaction and acidification with concentrated hydrochloric acid, the precipitated product was collected by filtration. Recrystallization from hot dimethyl sulfoxide by dilution with ethanol gives 0.53 g (66% yield) of product; m.p. 299°-301° C.

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationthe precipitated product was collected by filtration
  3. customRecrystallization from hot dimethyl sulfoxide by dilution with ethanol

Quellen und Nachweise

ORD-Eintrag
ord-ef57163a5e684e049f1b51872253b2cb
Quelldatensatz
uspto-grants-1988_03
Patentnummer
US04731368

Verknüpfte Notizen

Wird geladen…