HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Chloroisatoic anhydride → 2-amino-N-(4-bromo-2-fluorobenzyl)-4-chlorobenzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Chloroisatoic anhydride | HCID 329105 | — |
| Edukt | (4-Bromo-2-fluorophenyl)methanamine | HCID 3770848 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 2-amino-N-(4-bromo-2-fluorobenzyl)-4-chlorobenzamide | HCID 14458986 | 79,9% |
Reaktionsschritte
A mixture of 7-chloro-2H-3,1-benzoxazine-2,4(1H)dione (18.4 g) and 4-bromo-2-fluorobenzylamine (26 g) in tetrahydrofuran (200 ml) was refluxed for 15 minutes. After cooling, tetrahydrofuran was evaporated to give a residue. Recrystallization from isopropyl ether gave 2-amino-N-(4-bromo-2-fluorobenzyl)-4-chlorobenzamide (26.6 g).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04734419 |
| Quelldatensatz | uspto-grants-1988_03 |
| ORD ID | ord-403b2c40189f42a6a301c16ed594a458 |
| Quellennotiz | uspto-grants-1988_03 |