反应详情

A mixture of 7-chloro-2H-3,1-benzoxazine-2,4(1H)dione (18.4 g) and 4-bromo-2-fluorobenzylamine (26 g) in tetrahydrofuran (200 ml) was refluxed for 15 minutes. After cooling, tetrahydrofuran was evaporated to give a residue. Recrystallization from isopropyl ether gave 2-amino-N-(4-bromo-2-fluorobenzyl)-4-chlorobenzamide (26.6 g).

1. temperaturewas refluxed for 15 minutes
2. temperatureAfter cooling
3. customtetrahydrofuran was evaporated
4. customto give a residue
5. customRecrystallization from isopropyl ether