Methyl Acrylate → Methyl 3-(phenylthio)propionate

HRID 569852Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 569852
[C:1]1([SH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CCN(CC)CC.[C:15]([O:19][CH3:20])(=[O:18])[CH:16]=[CH2:17]>C(Cl)Cl>[C:1]1([S:7][CH2:17][CH2:16][C:15]([O:19][CH3:20])=[O:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

5

Edukt 3

HCID 7294Methyl AcrylateHCID 7969ThiophenolHCID 8471Triethylamine

Produkt 1

HCID 350367Methyl 3-(phenylthio)propionate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Thiophenol (440 mg, 4 mmol) and Et3N (70 μl, 0.5 mmol) were dissolved in CH2Cl2 (5 ml). Methyl acrylate (412 mg, 4.8 mmol) was added dropwise. The reaction was exothermic. After stirring at room temperature for 30 minutes, the excess methyl acrylate was removed in vacuo. TLC: silica gel, Et2O-hexane 1:2, UV Rf =0.58. The crude title ester was used without further purification.

Aufarbeitung

  1. customthe excess methyl acrylate was removed in vacuo
  2. customThe crude title ester was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-6a195b64aa2a438496a3d6a119203a0d
Quelldatensatz
uspto-grants-1988_03
Patentnummer
US04734426

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