Lithium Hydroxide → HCID 117622918, Verbindung

HRID 57058

Reaktionsgleichung

Reaktionsgleichung von HRID 57058
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:41]#[N:42])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:36][CH2:37][O:38][CH3:39])[C:17]([NH:19][C:20]3[CH:28]=[C:27]4[C:23]([CH:24]=[C:25]([C:29]([O:31]CC)=[O:30])[NH:26]4)=[CH:22][C:21]=3[O:34][CH3:35])=[O:18])[C:10](=[O:40])[CH:9]=2)[CH:7]=1.[OH-].[Li+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:41]#[N:42])=[C:6]([C:8]2[C:13]([O:14][CH3:15])=[CH:12][N:11]([CH:16]([CH2:36][CH2:37][O:38][CH3:39])[C:17]([NH:19][C:20]3[CH:28]=[C:27]4[C:23]([CH:24]=[C:25]([C:29]([OH:31])=[O:30])[NH:26]4)=[CH:22][C:21]=3[O:34][CH3:35])=[O:18])[C:10](=[O:40])[CH:9]=2)[CH:7]=1

Komponenten

3

Edukt 2

HCID 3939Lithium HydroxideHCID 117622475Ethyl 6-({2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxybutanoyl}amino)-5-methoxy-1H-indole-2-carboxylate

Produkt 1

HCID 117622918HCID 117622918, Verbindung

Versuchsvorschrift

80 mg (135 μmol) of ethyl 6-({2-[4-(5-chloro-2-cyanophenyl)-5-methoxy-2-oxopyridin-1(2H)-yl]-4-methoxybutanoyl}amino)-5-methoxy-1H-indole-2-carboxylate (racemate) were hydrolysed with lithium hydroxide at RT according to General Method 3. Yield: 63 mg (purity 90%, 74% of theory)

Quellen und Nachweise

ORD-Eintrag
ord-fcad36f0610f45c9b293400e464ea62d
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434690B2

Verknüpfte Notizen

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