Hydrogen iodide → HCID 178481972, Verbindung

HRID 570946Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 570946
I.[CH3:2][N:3]1[C:8](=[O:9])[N:7]2[CH:10]=[N:11][C:12]([C:13](=[NH:23])[NH:14][CH2:15][C:16](=O)[C:17]3[S:18][CH:19]=[CH:20][CH:21]=3)=[C:6]2[N:5]=[N:4]1.I>Cl>[CH3:2][N:3]1[C:8](=[O:9])[N:7]2[CH:10]=[N:11][C:12]([C:13]3[NH:14][CH:15]=[C:16]([C:17]4[S:18][CH:19]=[CH:20][CH:21]=4)[N:23]=3)=[C:6]2[N:5]=[N:4]1

Komponenten

4

Edukt 2

HCID 24841Hydrogen iodideHCID 1784819793-Methyl-4-oxo-N-(2-oxo-2-(thiophen-2-yl)ethyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboximidamide hydroiodide

Produkt 1

HCID 178481972HCID 178481972, VerbindungAusbeute 89,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel2×

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of crude 3-methyl-4-oxo-N-(2-oxo-2-(thiophen-2-yl)ethyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboximidamide hydroiodide (40 mg) in 3N HCl (3 mL) was heated at 80° C. overnight. After being cooled to room temperature, the mixture was left at 4° C. for 2 hours and the precipitate was filtered and washed successively with cold water, ethyl acetate and diethyl ether to give the a mixture of the hydrochloride and hydroiodide salts of the title compound (24 mg).

Aufarbeitung

  1. temperatureAfter being cooled to room temperature
  2. filtrationthe precipitate was filtered
  3. washwashed successively with cold water, ethyl acetate and diethyl ether
  4. customto give

Quellen und Nachweise

ORD-Eintrag
ord-d4c1abc50713406798b58db77ffdaf53
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09024018B2

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