Hydrogen iodide → HCID 178456698, Verbindung

HRID 570947Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 570947
I.[O:2]=[C:3]1[N:8]([CH2:9][C:10]#[CH:11])[N:7]=[N:6][C:5]2=[C:12]([C:15](=[NH:26])[NH:16][CH2:17][C:18](=O)[C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[N:13]=[CH:14][N:4]12.I>Cl>[C:19]1([C:18]2[N:26]=[C:15]([C:12]3[N:13]=[CH:14][N:4]4[C:3](=[O:2])[N:8]([CH2:9][C:10]#[CH:11])[N:7]=[N:6][C:5]=34)[NH:16][CH:17]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Komponenten

4

Edukt 2

HCID 24841Hydrogen iodideHCID 178456701HCID 178456701, Verbindung

Produkt 1

HCID 178456698HCID 178456698, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel2×

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of crude 4-oxo-N-(2-oxo-2-phenylethyl)-3-(prop-2-ynyl)-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboximidamide hydroiodide (45 mg) in 3N HCl (4 mL) was heated at 80° C. overnight. After being cooled to room temperature, the mixture was left at 4° C. for 2 hours and the precipitate was filtered and washed successively with cold water, ethyl acetate and diethyl ether to give a mixture of the hydrochloride and hydroiodide salts of the title compound.

Aufarbeitung

  1. temperatureAfter being cooled to room temperature
  2. filtrationthe precipitate was filtered
  3. washwashed successively with cold water, ethyl acetate and diethyl ether
  4. customto give

Quellen und Nachweise

ORD-Eintrag
ord-610222cf550e477a95a04448054d7917
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09024018B2

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