Triethylamine → 1-((2-(4-Methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-3-(quinolin-4-yl)urea

HRID 571987Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 571987
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([NH:11][C:12](=[O:20])OC2C=CC=CC=2)=[CH:3][CH:2]=1.[CH3:21][CH:22]1[CH2:27][CH2:26][N:25]([C:28]2[C:33]([CH2:34][NH2:35])=[CH:32][CH:31]=[C:30]([C:36]([F:39])([F:38])[F:37])[N:29]=2)[CH2:24][CH2:23]1.C(N(CC)CC)C>CS(C)=O.O>[CH3:21][CH:22]1[CH2:23][CH2:24][N:25]([C:28]2[C:33]([CH2:34][NH:35][C:12]([NH:11][C:4]3[C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[N:1]=[CH:2][CH:3]=3)=[O:20])=[CH:32][CH:31]=[C:30]([C:36]([F:39])([F:37])[F:38])[N:29]=2)[CH2:26][CH2:27]1

Komponenten

6

Edukt 3

HCID 8471TriethylamineHCID 58873687(2-(4-Methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methanamineHCID 86676323Phenyl quinolin-4-ylcarbamate

Produkt 1

HCID 712370471-((2-(4-Methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-3-(quinolin-4-yl)urea

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

Phenyl quinolin-4-ylcarbamate (crude 139 mg, 0.53 mmol) and (2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methanamine (144 mg, 0.53 mmol) were dissolved in dimethyl sulfoxide. Then triethylamine (0.15 mL, 1.06 mmol) was added to it. The mixture was stirred at room temperature for 12 h. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic layer was concentrated under reduced pressure.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. concentrationThe organic layer was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-2301d887842145e9a18c7953c24e5e43
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09029378B2

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