1-[4-(Benzyloxy)phenyl]-3-ethyl-1H-pyrazolo[3,4-b]pyridine → 4-(3-Ethyl-1H-pyrazolo[3,4-b]pyridin-1-yl)phenol

HRID 572174Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 572174
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[C:19]3=[N:20][CH:21]=[CH:22][CH:23]=[C:18]3[C:17]([CH2:24][CH3:25])=[N:16]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd].C(O)C>[CH2:24]([C:17]1[C:18]2[C:19](=[N:20][CH:21]=[CH:22][CH:23]=2)[N:15]([C:12]2[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=2)[N:16]=1)[CH3:25]

Komponenten

4

Edukt 1

HCID 867049821-[4-(Benzyloxy)phenyl]-3-ethyl-1H-pyrazolo[3,4-b]pyridine

Produkt 1

HCID 867049834-(3-Ethyl-1H-pyrazolo[3,4-b]pyridin-1-yl)phenolAusbeute 91,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 1-[4-(benzyloxy)phenyl]-3-ethyl-1H-pyrazolo[3,4-b]pyridine (300 mg), 10% palladium on carbon (containing water (50%), 97 mg) and ethanol (10 ml) was vigorously stirred under a hydrogen atmosphere at room temperature for 5 hr. The reaction mixture was filtered and the filtrate was concentrated to give the title compound (200 mg).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-f2f8545161374690b7943275a958663c
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09029388B2

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