Triethylamine → Ethyl 2-[4-(Methylsulfonamido)phenyl]acetate

HRID 572923Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 572923
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>ClCCl>[CH3:21][S:22]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:6][CH:7]=1)(=[O:24])=[O:23]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 225219p-Aminophenylacetic acid ethyl ester

Produkt 1

HCID 10038092Ethyl 2-[4-(Methylsulfonamido)phenyl]acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The solution of ethyl 2-(4-aminophenyl)acetate (500 mg, 2.79 mmol) and triethylamine (0.58 mL, 4.18 mmol) in dichloromethane (30 mL) was added methanesulfonyl chloride (0.24 mL, 3.07 mmol) dropwise at room temperature and stirred overnight. The mixture was washed with brine, dried over sodium sulfate and evaporated under reduced pressure. The residue was purified by a standard method to give desired compound. LC-MS: m/z (M+H)=258.3

Aufarbeitung

  1. washThe mixture was washed with brine
  2. dry with materialdried over sodium sulfate
  3. customevaporated under reduced pressure
  4. customThe residue was purified by a standard method

Quellen und Nachweise

ORD-Eintrag
ord-fb2d1e9b58c144f7bd732f22ef461a7e
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09029531B2

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