Lithium hydroxide, monohydrate → {4-[(Methanesulfonyl)amino]phenyl}acetic acid

HRID 572924Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 572924
[CH3:1][S:2]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C:13]([O:15]CC)=[O:14])=[CH:8][CH:7]=1)(=[O:4])=[O:3].O.[OH-].[Li+]>CO.O>[CH3:1][S:2]([NH:5][C:6]1[CH:7]=[CH:8][C:9]([CH2:12][C:13]([OH:15])=[O:14])=[CH:10][CH:11]=1)(=[O:4])=[O:3]

Komponenten

4

Edukt 2

HCID 168937Lithium hydroxide, monohydrateHCID 10038092Ethyl 2-[4-(Methylsulfonamido)phenyl]acetate

Produkt 1

HCID 2773887{4-[(Methanesulfonyl)amino]phenyl}acetic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 22242641Methanol--water (1/1)Lösungsmittel

Versuchsvorschrift

The solution of ethyl 2-(4-(methylsulfonamido)phenyl)acetate (200 mg, 0.77 mmol) and lithium hydroxide hydrate (130.4 mg, 3.11 mmol) in MeOH/H2O (10 mL, 1:1) was stirred at room temperature for 12 h. The reaction mixture was evaporated under reduced pressure. The residue was used for the next step without purification. LC-MS: m/z (M+H)=230.4

Aufarbeitung

  1. customThe reaction mixture was evaporated under reduced pressure
  2. customThe residue was used for the next step without purification

Quellen und Nachweise

ORD-Eintrag
ord-e3e3229ae30e41c4a9a2ba4fe8f9b1fb
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09029531B2

Notizen zur Reaktion

Wird geladen…