Sodium Chloride → Methyl (5-nitropyridin-2-yl)acetate

HRID 572929Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 572929
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH:10](C(OC)=O)[C:11]([O:13][CH3:14])=[O:12])=[N:8][CH:9]=1)([O-:3])=[O:2].[Na+].[Cl-]>CS(C)=O.O>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[N:8][CH:9]=1)([O-:3])=[O:2]

Komponenten

5

Edukt 2

HCID 5234Sodium ChlorideHCID 2764544HCID 2764544, Verbindung

Produkt 1

HCID 51341867Methyl (5-nitropyridin-2-yl)acetate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 679Dimethyl SulfoxideLösungsmittelHCID 962WaterLösungsmittel2×

Versuchsvorschrift

The solution of dimethyl 2-(5-nitropyridin-2-yl)malonate (10.0 g 41.7 mmol), NaCl (2.58 g, 44.20 mmol) and H2O (1.3 g, 74.23 mmol) in DMSO (50 mL) was stirred at 130 degree for 6 h. After cooling to room temperature, the reaction mixture was diluted with H2O and extracted with ethyl acetate. The organic layer was dried over sodium sulfate and evaporated under reduced pressure. The residue was purified by a standard method to get desired product.

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. customevaporated under reduced pressure
  4. customThe residue was purified by a standard method

Quellen und Nachweise

ORD-Eintrag
ord-65d7e2eb10ee4845b9559317c9238678
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09029531B2

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