Hydrochloric Acid → 1-(Oxan-4-yl)piperazine--hydrogen chloride (1/2)

HRID 573138Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 573138
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[ClH:20]>CCOCC>[ClH:20].[ClH:20].[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 46785855HCID 46785855, Verbindung

Produkt 1

HCID 441204811-(Oxan-4-yl)piperazine--hydrogen chloride (1/2)

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

To a solution of EXAMPLE 336A (3.92 g) in ether was added HCl (25 mL, 2M in ether) and the reaction mixture was stirred for 16 hours at room temperature. The solid product was filtered off, dried and used in next step without further purification.

Aufarbeitung

  1. filtrationThe solid product was filtered off
  2. customdried
  3. customused in next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-c98295b97b0b4652be6e774b9282960a
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09029404B2

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