Iodoethane → Methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate

HRID 573342Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 573342
[N+:1]([C:4]1[C:5]([C:9]([O:11][CH3:12])=[O:10])=[N:6][NH:7][CH:8]=1)([O-:3])=[O:2].[CH2:13](I)[CH3:14].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[CH2:13]([N:6]1[C:5]([C:9]([O:11][CH3:12])=[O:10])=[C:4]([N+:1]([O-:3])=[O:2])[CH:8]=[N:7]1)[CH3:14]

Komponenten

5

Edukt 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 178499180HCID 178499180, Verbindung

Produkt 1

HCID 54775328Methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

A mixture of methyl 4-nitro-1H-pyrazole-3-carboxylate (5.0 g), EtI (2.8 mL) and K2CO3 (8.1 g) in acetone (50 mL) was stirred at 50° C. for 4 h. After stirring at room temperature overnight, the mixture was filtered and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (AcOEt/hexane) to give the title compound (2.2 g).

Aufarbeitung

  1. stirringAfter stirring at room temperature overnight
  2. filtrationthe mixture was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customThe residue was purified by silica gel column chromatography (AcOEt/hexane)

Quellen und Nachweise

ORD-Eintrag
ord-81918841e50747d593bb1ef17f22d105
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09029536B2

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