Methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate → Methyl 4-amino-1-ethyl-1H-pyrazole-5-carboxylate

HRID 573343Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 573343
[CH2:1]([N:3]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:6]([N+:12]([O-])=O)[CH:5]=[N:4]1)[CH3:2]>CO.[Pd]>[NH2:12][C:6]1[CH:5]=[N:4][N:3]([CH2:1][CH3:2])[C:7]=1[C:8]([O:10][CH3:11])=[O:9]

Komponenten

4

Edukt 1

HCID 54775328Methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate

Produkt 1

HCID 54775640Methyl 4-amino-1-ethyl-1H-pyrazole-5-carboxylateAusbeute 96,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of methyl 1-ethyl-4-nitro-1H-pyrazole-5-carboxylate (2.2 g) and 10% Pd—C (0.60 g) in MeOH (30 mL) was hydrogenated under balloon pressure at room temperature overnight. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give the title compound (1.8 g).

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0bafab80cc2d4d5489845deb549d1470
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09029536B2

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