Diisopropylethylamine → HCID 178463033, Verbindung

HRID 573344Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 573344
[NH2:1][C:2]1[CH:3]=[N:4][N:5]([CH2:11][CH3:12])[C:6]=1[C:7]([O:9]C)=O.C(O)(=O)C.[CH:17](N)=[NH:18].CCN(C(C)C)C(C)C>C(O)CCC>[CH2:11]([N:5]1[C:6]2[C:7]([OH:9])=[N:18][CH:17]=[N:1][C:2]=2[CH:3]=[N:4]1)[CH3:12]

Komponenten

5

Edukt 3

HCID 81531DiisopropylethylamineHCID 160693Formamidine acetateHCID 54775640Methyl 4-amino-1-ethyl-1H-pyrazole-5-carboxylate

Produkt 1

HCID 178463033HCID 178463033, VerbindungAusbeute 86,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Reaktionsbedingungen

Temperatur
120 °C

Versuchsvorschrift

A mixture of methyl 4-amino-1-ethyl-1H-pyrazole-5-carboxylate (1.75 g), formamidine acetate (1.615 g), n-butanol (20 mL) and DIPEA (20 mL) was stirred at 120° C. for 3 h. The mixture was concentrated under reduced pressure, and the residual crystals were washed with AcOEt/hexane to give the title compound (1.47 g).

Aufarbeitung

  1. concentrationThe mixture was concentrated under reduced pressure
  2. washthe residual crystals were washed with AcOEt/hexane

Quellen und Nachweise

ORD-Eintrag
ord-281c048aa3bc4786a9fa55ad353ca83f
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09029536B2

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