7-Chloro-1-ethyl-1H-pyrazolo[4,3-d]pyrimidine → HCID 66727973, Verbindung

HRID 573346Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 573346
Cl[C:2]1[C:3]2[N:10]([CH2:11][CH3:12])[N:9]=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1>CCOC(C)=O.[Pd]>[CH2:11]([N:10]1[C:3]2[CH:2]=[N:7][CH:6]=[N:5][C:4]=2[CH:8]=[N:9]1)[CH3:12]

Komponenten

4

Edukt 1

HCID 714458087-Chloro-1-ethyl-1H-pyrazolo[4,3-d]pyrimidine

Produkt 1

HCID 66727973HCID 66727973, VerbindungAusbeute 93,9 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A mixture of 7-chloro-1-ethyl-1H-pyrazolo[4,3-d]pyrimidine (105 mg), TEA (0.088 mL) and 10% Pd—C (30 mg) in AcOEt (5 mL) was hydrogenated under balloon pressure at room temperature for 2 h. The catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to give the title compound (80 mg).

Aufarbeitung

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-82466f85a4994758adcb1ded58cd0c9f
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09029536B2

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