Water → HCID 66727811, Verbindung

HRID 573356

Reaktionsgleichung

Reaktionsgleichung von HRID 573356
[CH3:1][S:2][C:3]1[NH:11][C:6]2=[N:7][CH:8]=[CH:9][CH:10]=[C:5]2[N:4]=1.FC(F)(F)S(O[CH2:18][CH:19]([F:21])[F:20])(=O)=O.O>CN(C=O)C>[F:20][CH:19]([F:21])[CH2:18][N:11]1[C:6]2=[N:7][CH:8]=[CH:9][CH:10]=[C:5]2[N:4]=[C:3]1[S:2][CH3:1]

Komponenten

5

Edukt 3

HCID 962WaterHCID 27740892,2-Difluoroethyl trifluoromethanesulfonateHCID 178503348HCID 178503348, Verbindung

Produkt 1

HCID 66727811HCID 66727811, VerbindungAusbeute 48 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

A mixture of 2-(methylsulfanyl)-3H-imidazo[4,5-b]pyridine (600 mg) and 2,2-difluoroethyl trifluoromethanesulfonate (816 mg) in DMF (7 mL) was stirred at 80° C. for 3 h, treated with water, and extracted with AcOEt. The organic layer was dried over MgSO4 and concentrated under reduced pressure to give the title compound (400 mg).

Aufarbeitung

  1. extractionextracted with AcOEt
  2. dry with materialThe organic layer was dried over MgSO4
  3. concentrationconcentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-2d9016d9496f45a1ab6f94d4a0165361
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09029536B2

Verknüpfte Notizen

Wird geladen…