Hydrochloric Acid → Ethyl 1-({amino[3-(trifluoromethyl)phenyl}acetyl]amino)cyclopropanecarboxylate hydrochloride

HRID 574151

Reaktionsgleichung

Reaktionsgleichung von HRID 574151
C(OC([NH:8][CH:9]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:30])([F:29])[F:28])[CH:22]=1)[C:10]([NH:12][C:13]1([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:15][CH2:14]1)=[O:11])=O)(C)(C)C.[ClH:31]>ClCCl.O1CCOCC1>[ClH:31].[NH2:8][CH:9]([C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([C:27]([F:28])([F:29])[F:30])[CH:22]=1)[C:10]([NH:12][C:13]1([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:14][CH2:15]1)=[O:11]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 66801809Ethyl 1-({[(tert-butoxycarbonyl)amino][3-(trifluoromethyl)phenyl]acetyl}amino)cyclopropanecarboxylate

Produkt 1

HCID 89780476Ethyl 1-({amino[3-(trifluoromethyl)phenyl}acetyl]amino)cyclopropanecarboxylate hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

262 mg (0.61 mmol) of the compound of Example 17A were dissolved in 4 ml of dichloromethane, and 4 ml of a 4N solution of hydrogen chloride in dioxane were added. The solution was stirred at RT for 3 h and then freed from the volatile components on a rotary evaporator. The residue was dried under high vacuum. This gave 223 mg (quant.) of the title compound.

Aufarbeitung

  1. customfreed from the volatile components on a rotary evaporator
  2. customThe residue was dried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-63ef24af7ed74888b706354e023f6057
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09034855B2

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