Water → 6-(Pyridin-2-yl)pyridazine-3-thiol

HRID 574183

Reaktionsgleichung

Reaktionsgleichung von HRID 574183
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10](=O)[NH:11][N:12]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:15].O>N1C=CC=CC=1>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:8]=[CH:9][C:10](=[S:15])[NH:11][N:12]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 14817Phosphorus sulfide (P2S5)HCID 49800226-(Pyridin-2-yl)pyridazin-3-ol

Produkt 1

HCID 49800236-(Pyridin-2-yl)pyridazine-3-thiolAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

500 mg (2.9 mmol) of pyridazinone 7 and 772 mg (3.5 mmol) of phosphorus pentasulfide are dissolved in 20 ml of anhydrous pyridine. The reaction mixture is brought to reflux for 18 h, and then cooled to ambient temperature. It is then poured into 200 ml of water, and the precipitate thus formed is filtered off and then washed with ice-cold water. The pyridazinethione 10 is obtained with a yield of 92%.

Aufarbeitung

  1. temperatureto reflux for 18 h
  2. customthe precipitate thus formed
  3. filtrationis filtered off
  4. washwashed with ice-cold water

Quellen und Nachweise

ORD-Eintrag
ord-ee53a89773d24a1ea64a87dac1a80651
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09034873B2

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