Water → 3-(2-Carboxypyridin-6-yl)-6-(pyridin-2-yl)-pyridazine

HRID 574190Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 574190
[CH3:1][C:2]1[N:7]=[C:6]([C:8]2[N:9]=[N:10][C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)=[CH:12][CH:13]=2)[CH:5]=[CH:4][CH:3]=1.[Se](=O)=[O:21].ClC1C=CC=CC=1Cl.[OH2:31]>>[C:1]([C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([C:8]2[N:9]=[N:10][C:11]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=3)=[CH:12][CH:13]=2)[N:7]=1)([OH:21])=[O:31]

Komponenten

5

Edukt 4

HCID 962WaterHCID 72391,2-DichlorobenzeneHCID 24007Selenium DioxideHCID 64179693-(6-Methylpyridin-2-yl)-6-(pyridin-2-yl)pyridazine

Produkt 1

HCID 64179713-(2-Carboxypyridin-6-yl)-6-(pyridin-2-yl)-pyridazineAusbeute 74 %

Reaktionsbedingungen

Temperatur
150 °C

Versuchsvorschrift

400 mg (2.42 mmol) of pyridazine 44, 177 mg (1.60 mmol) of selenium dioxide and 7 ml of o-dichlorobenzene are introduced into a 100 ml round-bottomed flask equipped with a condenser. The mixture is heated at 150° C. for 4 hours, and then cooled to ambient temperature. An excess of water is added to the precipitate formed, which is filtered off and washed with water. The solid obtained is dried, so as to give the acid 45 with a yield of 74%.

Aufarbeitung

  1. customequipped with a condenser
  2. temperaturecooled to ambient temperature
  3. customformed
  4. filtrationwhich is filtered off
  5. washwashed with water
  6. customThe solid obtained
  7. customis dried

Quellen und Nachweise

ORD-Eintrag
ord-862c866f606343ffa9b1bf435279761d
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09034873B2

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