Acetic Acid → HCID 178489574, Verbindung

HRID 574318

Reaktionsgleichung

Reaktionsgleichung von HRID 574318
[N:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][CH3:11])=[C:2]=[S:3].C[O:13][C:14](=O)[C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][C:16]=1[NH2:22].C(O)(=O)C>C(O)C>[SH:3][C:2]1[N:1]([C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=2[O:10][CH3:11])[C:14](=[O:13])[C:15]2[C:16](=[CH:17][C:18]([CH3:21])=[CH:19][CH:20]=2)[N:22]=1

Komponenten

5

Edukt 3

HCID 176Acetic AcidHCID 5205992-Methoxyphenyl IsothiocyanateHCID 11205965Methyl 2-amino-4-methylbenzoate

Produkt 1

HCID 178489574HCID 178489574, VerbindungAusbeute 62 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

1-Isothiocyanato-2-methoxy-benzene (0.76 mL, 5.45 mmol) was added to a solution of 2-amino-4-methyl-benzoic acid methyl ester (900 mg, 5.45 mmol) and acetic acid (1.5 mL) in ethanol (10 mL), and heated at reflux for 16 hr. The reaction mixture was cooled to room temperature and diluted with ethanol. The precipitated solid was filtered, washed with ethanol and dried to afford 2-mercapto-3-(2-methoxy-phenyl)-7-methyl-3H-quinazolin-4-one (1.0 g, 62%) as white solid.

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux for 16 hr
  3. filtrationThe precipitated solid was filtered
  4. washwashed with ethanol
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-f00a564f82cb40d49009fa43b4a6a418
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09034887B2

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