Diethyl Ether → HCID 178418743, Verbindung

HRID 574696

Reaktionsgleichung

Reaktionsgleichung von HRID 574696
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH2:10][OH:11])=[CH:9][C:4]=2[N:3]=[CH:2]1.C[N+]1([O-])CCOCC1.CCOCC>ClCCl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([CH:10]=[O:11])=[CH:9][C:4]=2[N:3]=[CH:2]1

Komponenten

6

Edukt 3

HCID 3283Diethyl EtherHCID 82029Methyl morpholine oxideHCID 178519339HCID 178519339, Verbindung

Produkt 1

HCID 178418743HCID 178418743, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178419074HCID 178419074, VerbindungKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

(1H-benzo[d]imidazole-5-yl)methanol (2.8 mmol, 1 eq.) was dissolved in 30 mL dichloromethane and a molecular sieve (4 A) was added. To the solution were added Tetrapropylammonium perruthenate (0.28 mmol, 0.1 eq.) and N-Methylmorpholine-N-Oxide (9.8 mmol, 3.5 eq.). After stirring the mixture for 72 hours at room temperature 50 mL of ether was added and filtrated. The solvent was removed under reduced pressure and the product was purified by means of flash-chromatography using silica gel and a ethyl acetate/MeOH-gradient.

Aufarbeitung

  1. additiona molecular sieve (4 A) was added
  2. additionwas added
  3. filtrationfiltrated
  4. customThe solvent was removed under reduced pressure
  5. customthe product was purified by means of flash-chromatography

Quellen und Nachweise

ORD-Eintrag
ord-12dc541905d04133a437a9cab93dbb56
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09034907B2

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