Dichloromethane → HCID 178513779, Verbindung

HRID 575394

Reaktionsgleichung

Reaktionsgleichung von HRID 575394
[CH2:1]1[CH:3]([C:4]([NH2:6])=N)[CH2:2]1.Cl.[Br:8][C:9]1[CH:10]=[CH:11][C:12]2[O:18][CH2:17][CH2:16][N:15]3[C:19](I)=[C:20]([C:22]([NH2:24])=[O:23])[N:21]=[C:14]3[C:13]=2[CH:26]=1.[NH2:27][NH2:28].[CH2:29](Cl)Cl>>[Br:8][C:9]1[CH:10]=[CH:11][C:12]2[O:18][CH2:17][CH2:16][N:15]3[C:19]([C:29]4[NH:28][N:27]=[C:4]([CH:3]5[CH2:1][CH2:2]5)[N:6]=4)=[C:20]([C:22]([NH2:24])=[O:23])[N:21]=[C:14]3[C:13]=2[CH:26]=1

Komponenten

5

Edukt 4

HCID 6344DichloromethaneHCID 9321HydrazineHCID 2781916Cyclopropanecarboximidamide hydrochlorideHCID 8669319110-Bromo-3-iodo-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide

Produkt 1

HCID 178513779HCID 178513779, VerbindungAusbeute 31 %

Versuchsvorschrift

10-bromo-3-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was prepared similarly according to Procedure I. Cyclopropylcarboxamidine hydrochloride was reacted with 10-bromo-3-iodo-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine-2-carboxamide then hydrazine. The completed reaction was then diluted with methylene chloride and filtered over celite to afford 83 mg (31% yield) of the title compound.

Aufarbeitung

  1. custom10-bromo-3-(3-cyclopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepine-2-carboxamide was prepared similarly
  2. customThe completed reaction
  3. filtrationfiltered over celite

Quellen und Nachweise

ORD-Eintrag
ord-8d6fb55e07f146a7ad8eb62fa058d146
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09034866B2

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