Phosphorus pentachloride → (1-Methyl-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroquinol-4-yl)-methane-sulfonic acid chloride

HRID 575514Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 575514
[CH2:1]([N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][CH3:14])[CH:11]=2)[C:6]([CH2:15][S:16](O)(=[O:18])=[O:17])=[CH:5][C:4]1([CH3:21])[CH3:20])C.CN1C2C(=CC=C(OC)C=2)C(CS(O)(=O)=O)CC1(C)C.P(Cl)(Cl)(Cl)(Cl)[Cl:43]>>[CH3:1][N:3]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:13][CH3:14])[CH:11]=2)[CH:6]([CH2:15][S:16]([Cl:43])(=[O:18])=[O:17])[CH2:5][C:4]1([CH3:21])[CH3:20]

Komponenten

4

Edukt 3

HCID 24819Phosphorus pentachlorideHCID 12138186(1-Methyl-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroquinol-4-yl)-methanesulfonic acidHCID 12138189(1-Ethyl-7-methoxy-2,2-dimethyl-1,2-dihydroquinol-4-yl)-methanesulfonic acid

Produkt 1

HCID 12138193(1-Methyl-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroquinol-4-yl)-methane-sulfonic acid chlorideAusbeute 78 %

Versuchsvorschrift

(1-Methyl-7-methoxy-2,2-dimethyl-1,2,3,4-tetrahydroquinol-4-yl)-methane-sulfonic acid chloride (19) is prepared similarly to compound (16) using compound (3) and phosphorus pentachloride except that it is stirred for 18 hours at room temperature.

Quellen und Nachweise

ORD-Eintrag
ord-196cf0649ee84b8b934f3a91faf7e647
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09035042B2

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