p-Bromobenzenesulfonyl chloride → 4-[(4-Bromobenzene)sulfonyl]morpholine

HRID 57561

Reaktionsgleichung

Reaktionsgleichung von HRID 57561
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[CH:4][CH:3]=1.C(N(CC)CC)C.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 7396p-Bromobenzenesulfonyl chlorideHCID 8083MorpholineHCID 8471Triethylamine

Produkt 1

HCID 2531284-[(4-Bromobenzene)sulfonyl]morpholine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 4-bromobenzene-1-sulfonyl chloride (2.56 g, 10.0 mmol) and triethylamine (1.82 mL, 13 mmol) in DCM (50 mL) was added morpholine (960 mg, 11.0 mmol) dropwise and the mixture was stirred for 30 minutes at room temperature. Then the mixture was concentrated and extracted with EA, washed with 0.1M HCl water solution (2×100 mL), NaHCO3 solution (2×100 mL) and brine, dried and concentrated to give product as a white solid.

Aufarbeitung

  1. concentrationThen the mixture was concentrated
  2. extractionextracted with EA
  3. washwashed with 0.1M HCl water solution (2×100 mL), NaHCO3 solution (2×100 mL) and brine
  4. customdried
  5. concentrationconcentrated
  6. customto give product as a white solid

Quellen und Nachweise

ORD-Eintrag
ord-9433996ce9ba462fa4ebac1f06a03aee
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434726B2

Verknüpfte Notizen

Wird geladen…