4-methyl-8-nitro-2H-1,4-benzoxazin-3(4H)-one → 8-Amino-4-methyl-2H-1,4-benzoxazin-3(4H)-one

HRID 576074Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 576074
[CH3:1][N:2]1[C:7]2[CH:8]=[CH:9][CH:10]=[C:11]([N+:12]([O-])=O)[C:6]=2[O:5][CH2:4][C:3]1=[O:15]>C(O)C.[Pd]>[NH2:12][C:11]1[C:6]2[O:5][CH2:4][C:3](=[O:15])[N:2]([CH3:1])[C:7]=2[CH:8]=[CH:9][CH:10]=1

Komponenten

4

Edukt 1

HCID 389971764-methyl-8-nitro-2H-1,4-benzoxazin-3(4H)-one

Produkt 1

HCID 263703078-Amino-4-methyl-2H-1,4-benzoxazin-3(4H)-oneAusbeute 88,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

To a solution of 4-methyl-8-nitro-2 H-1,4-benzoxazin-3(4 H)-one (415 mg, 1.99 mmol) in ethanol (10 mL) was added 10% palladium activated carbon (415 mg) at room temperature, and the mixture was stirred overnight under a hydrogen atmosphere. The reaction mixture was filtered through Celite (registered trademark), followed by washing with ethanol. The filtrate was concentrated under reduced pressure. The resulting residue was dried under reduced pressure to afford the title compound as a gray powder (314 mg).

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite (registered trademark)
  2. washby washing with ethanol
  3. concentrationThe filtrate was concentrated under reduced pressure
  4. customThe resulting residue was dried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-862f18eab74f4ad4bcf8f898dc1d921c
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09035059B2

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