Hydrochloric Acid → 2-Nitro-5-(3-hydroxyphenylthio)-p-xylene

HRID 576480Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 576480
[SH:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.[N+:9]([C:12]1[CH:17]=[C:16]([CH3:18])[C:15](Br)=[CH:14][C:13]=1[CH3:20])([O-:11])=[O:10].C([O-])([O-])=O.[K+].[K+].Cl>CN(C)C=O.O>[N+:9]([C:12]1[CH:17]=[C:16]([CH3:18])[C:15]([S:1][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[CH:3]=2)=[CH:14][C:13]=1[CH3:20])([O-:11])=[O:10]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 8258081-Bromo-2,5-dimethyl-4-nitrobenzeneHCID 27366133-Hydroxybenzenethiol

Produkt 1

HCID 665838602-Nitro-5-(3-hydroxyphenylthio)-p-xyleneAusbeute 50,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A mixture of 18.9 g of 3-mercaptophenol (0.150 moles), 32.9 g of 2-nitro-5-bromo-p-xylene (0.143 moles) and K2CO3 (0.143 moles) in 95 ml of N,N-dimethylformamide is stirred at room temperature for 2 hours. A solution of HCl at 10% is added under stirring; the mixture is diluted with H2O and extracted with ethyl acetate. The organic phase is washed again with water, anhydrified on sodium sulfate, filtered and evaporated. 20 g of solid product are obtained, which is used as such for the subsequent reaction.

Aufarbeitung

  1. stirringunder stirring
  2. extractionextracted with ethyl acetate
  3. washThe organic phase is washed again with water
  4. filtrationfiltered
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-e429364762db4c338b73196e58fb53c4
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09040457B2

Notizen zur Reaktion

Wird geladen…