Diisopropylethylamine → HCID 178499453, Verbindung

HRID 576659Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 576659
Cl[C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][N+:3]=1[O-:13].CCN(C(C)C)C(C)C.[NH2:23][CH2:24][CH2:25][NH:26][C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30]>CC(O)(C)C>[C:29]([O:28][C:27]([NH:26][CH2:25][CH2:24][NH:23][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:11][CH3:12])=[O:10])=[CH:4][N+:3]=1[O-:13])=[O:33])([CH3:32])([CH3:31])[CH3:30]

Komponenten

5

Edukt 3

HCID 81531DiisopropylethylamineHCID 187201N-BOC-ethylenediamineHCID 59464117HCID 59464117, Verbindung

Produkt 1

HCID 178499453HCID 178499453, VerbindungAusbeute 32,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6386tert-ButanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To 2-chloro-5-(2-methoxy-2-oxoethyl)pyridine 1-oxide (2.5 g) in t-BuOH (50 mL) was added DIEA (3.4 mL) and tert-butyl 2-aminoethylcarbamate (3.0 g). The resulting reaction mixture was stirred at 80° C. for 2 days. The solvent was then removed and the residue purified by reverse phase chromatography to afford the desired product (1.3 g).

Aufarbeitung

  1. customThe resulting reaction mixture
  2. customThe solvent was then removed
  3. customthe residue purified by reverse phase chromatography

Quellen und Nachweise

ORD-Eintrag
ord-9492210acb694b7d8711dd1f333c4dae
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09040504B2

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