Diisopropylethylamine → 6-({2-[(5,7-Dimethyl-2-phenylimidazo[5,1-f][1,2,4]triazin-4-yl)amino]ethyl}amino)nicotinonitrile

HRID 57711

Reaktionsgleichung

Cl[C:2]1[C:7]2=[C:8]([CH3:12])[N:9]=[C:10]([CH3:11])[N:6]2[N:5]=[C:4]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:3]=1.Cl.Cl.[NH2:21][CH2:22][CH2:23][NH:24][C:25]1[CH:32]=[CH:31][C:28]([C:29]#[N:30])=[CH:27][N:26]=1.C(N(CC)C(C)C)(C)C>CS(C)=O>[CH3:12][C:8]1[N:9]=[C:10]([CH3:11])[N:6]2[C:7]=1[C:2]([NH:21][CH2:22][CH2:23][NH:24][C:25]1[CH:32]=[CH:31][C:28]([C:29]#[N:30])=[CH:27][N:26]=1)=[N:3][C:4]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[N:5]2

Komponenten

Reaktionsbedingungen

Temperatur: 150 °C

Versuchsvorschrift

183 mg (0.71 mmol) of the 4-chloro-5,7-dimethyl-2-phenylimidazo[5,1-f][1,2,4]triazine (Example 16A) were initially charged in 4 ml of DMSO, and 200 mg (0.85 mmol) of 6-[(2-aminoethyl)-amino]nicotinonitrile (Example 2A) and 1.23 ml (7 mmol) of N,N-diisopropylethylamine were added and the mixture was heated at 150° C. for 12 h. Purification by chromatography on silica gel (mobile phase: dichloromethane/methanol 100:1) gave 10 mg (4% of theory) of the product.

Aufarbeitung

customPurification by chromatography on silica gel (mobile phase: dichloromethane/methanol 100:1)
customgave 10 mg (4% of theory) of the product

Quellen und Nachweise

ORD-Eintrag: ord-278bd82f4d9d4e7f9e9fca8e2c5feb47
Quelldatensatz: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US09434731B2

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