2,2-Dimethoxypropane → HCID 67356722, Verbindung

HRID 577827Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 577827
[F:1][C:2]1[C:9]([F:10])=[C:8]([F:11])C=C[C:3]=1[CH:4]=O.[CH3:12][O:13][C:14]([O:17][CH3:18])(C)[CH3:15]>CCOCC.CC1C=CC(S(O)(=O)=O)=CC=1>[CH3:12][O:13][CH:14]([O:17][CH3:18])[C:15]1[CH:4]=[CH:3][C:2]([F:1])=[C:9]([F:10])[C:8]=1[F:11]

Komponenten

5

Edukt 2

HCID 64952,2-DimethoxypropaneHCID 5192262,3,4-Trifluorobenzaldehyde

Produkt 1

HCID 67356722HCID 67356722, VerbindungAusbeute 71,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6101p-Toluenesulfonic acidKatalysatorHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A solution of 2,3,4-trifluorobenzaldehyde (25 g, 156.16 mmol), 2,2-dimethoxypropane (58.1 ml, 468.48 mmol), and 4-methylbenzenesulfonic acid (0.269 g, 1.56 mmol) was stirred at room temperature overnight. The reaction mixture diluted with ether and washed successively with aq. sodium bicarbonate solution, water, and brine. The organic layer dried over sodium sulfate and concentrated. The residue was distilled under high vacuum to give the title compound (23.07 g, 71.7%).

Aufarbeitung

  1. washwashed successively with aq. sodium bicarbonate solution, water, and brine
  2. dry with materialThe organic layer dried over sodium sulfate
  3. concentrationconcentrated
  4. distillationThe residue was distilled under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-73668a9afa6d497f8d3d0788b8be06b6
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09040528B2

Notizen zur Reaktion

Wird geladen…