Decanoic Acid → Risperidone Decanoate

HRID 578738

Reaktionsgleichung

Reaktionsgleichung von HRID 578738
[CH3:1][C:2]1[N:12]=[C:11]2[N:6]([CH2:7][CH2:8][CH2:9][CH2:10]2)[C:4](=[O:5])[C:3]=1[CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][CH:18]([C:21]2[C:22]3[CH:23]=[CH:24][C:25]([F:30])=[CH:26][C:27]=3[O:28][N:29]=2)[CH2:17][CH2:16]1.[C:31]([OH:42])(=[O:41])[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40]>C(O)C>[CH3:1][C:2]1[N:12]=[C:11]2[N:6]([CH2:7][CH2:8][CH2:9][CH2:10]2)[C:4](=[O:5])[C:3]=1[CH2:13][CH2:14][N:15]1[CH2:20][CH2:19][CH:18]([C:21]2[C:22]3[CH:23]=[CH:24][C:25]([F:30])=[CH:26][C:27]=3[O:28][N:29]=2)[CH2:17][CH2:16]1.[C:31]([O-:42])(=[O:41])[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40]

Komponenten

4

Edukt 2

HCID 2969Decanoic AcidHCID 5073Risperidone

Produkt 1

HCID 131732870Risperidone Decanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Reaktionsbedingungen

Temperatur
52.5 °C

Versuchsvorschrift

150 ml of ethanol and 5 gm Risperidone were charged in the flask. The reaction mixture was heated at 50-55° C. and stirred for 10 minutes to get clear solution. 2.1 gm decanoic acid solution in 30 ml ethanol was added to the reaction mixture at 40-45° C. The reaction mixture was further cooled to 25-30° C., stirred for 18-20 hours and distilled out completely under vacuum at 50-55° C. The solid was dried under vacuum at 40-45° C.

Aufarbeitung

  1. customto get clear solution
  2. temperatureThe reaction mixture was further cooled to 25-30° C.
  3. stirringstirred for 18-20 hours
  4. distillationdistilled out completely under vacuum at 50-55° C
  5. customThe solid was dried under vacuum at 40-45° C.

Quellen und Nachweise

ORD-Eintrag
ord-d79fd3f721be46d5aad743def91d2ae3
Quelldatensatz
uspto-grants-2015_05
Patentnummer
US09040695B2

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