HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 579788Erstellt: 26. Oktober 2026
2-(Methylthio)thiazolo[5,4-b]pyridine → 1-acetyl-N-(thiazolo[5,4-b]pyridin-2-yl)-4-piperidinemethanamine
https://huagongshe.com/reaction/579788
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 2-(Methylthio)thiazolo[5,4-b]pyridine | HCID 699840 | — |
| Edukt | 2,3-Dihydro-1,4-benzodioxin-6-yl isothiocyanate | HCID 2776173 | — |
| Edukt | 1-(4-(Aminomethyl)piperidin-1-yl)ethan-1-one | HCID 12687022 | — |
| Produkt | 1-acetyl-N-(thiazolo[5,4-b]pyridin-2-yl)-4-piperidinemethanamine | HCID 21241575 | 93% |
Reaktionsschritte
A mixture of 11 parts of 1-acetyl-4-piperidinemethanamine and 9 parts of 2-(methylthio)thiazolo[5,4-b]pyridine was stirred and heated for 20 hours at 140° C. The whole was purified by column chromatography over silica gel using a mixture of trichloromethane and methanol (95:5 by volume) as eluent. The pure fractions were collected and the eluent was evaporated, yielding 13.5 parts (93%) of 1-acetyl-N-(thiazolo[5,4-b]-pyridin-2-yl)-4-piperidinemethanamine as a residue (intermediate 51).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US04749702 |
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| Quelldatensatz | uspto-grants-1988_06 |
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| ORD ID | ord-18f857e80ac7404e92acdc90022a1021 |
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| Quellennotiz | uspto-grants-1988_06 |
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