Ammonia → HCID 19794224, Verbindung

HRID 5798

Reaktionsgleichung

Reaktionsgleichung von HRID 5798
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12](=[O:15])[NH:13][N:14]=2)=[CH:5][CH:4]=1.O1[CH:21]=[CH:20][C:19](=[O:22])[CH:18]=[CH:17]1.N>O>[O:22]=[C:19]1[CH:20]=[CH:21][N:2]([C:3]2[CH:8]=[CH:7][C:6]([C:9]3[CH:10]=[CH:11][C:12](=[O:15])[NH:13][N:14]=3)=[CH:5][CH:4]=2)[CH:17]=[CH:18]1

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 79684H-pyran-4-oneHCID 121965736-(4-aminophenyl)-3(2H)-pyridazinone hydrochloride

Produkt 1

HCID 19794224HCID 19794224, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

A stirred mixture of 6-(4-aminophenyl)-3(2H)-pyridazinone hydrochloride (1.5 g), 4H-pyran-4-one (0.71 g), and water (20 ml), was heated under reflux for 2 hours. The pH of the hot solution was adjusted to 8 with aqueous ammonia and the mixture was cooled to give the crude product, 1.84 g, m.p. 338°-340° C. Recrystallisation from aqueous ethanol gave the title compound, 1.4 g, m.p. 339°-341° C.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. temperaturethe mixture was cooled
  4. customto give the crude product, 1.84 g, m.p. 338°-340° C
  5. customRecrystallisation from aqueous ethanol

Quellen und Nachweise

ORD-Eintrag
ord-2e0927e1207d4f81994448ab79173b02
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05246928

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