Potassium Iodide → HCID 86754176, Verbindung

HRID 581066Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 581066
BrBr.Br[CH2:4][CH2:5][O:6][C:7]1[C:16]2[O:15][CH2:14][CH2:13][O:12][C:11]=2[CH:10]=[CH:9][CH:8]=1.[C:17]1(=[O:27])[NH:21][C:20](=[O:22])[C:19]2=[CH:23][CH:24]=[CH:25][CH:26]=[C:18]12.[K].[I-].[K+]>CN(C)C=O>[O:12]1[C:11]2[CH:10]=[CH:9][CH:8]=[C:7]([O:6][CH2:5][CH2:4][N:21]3[C:17](=[O:27])[C:18]4[C:19](=[CH:23][CH:24]=[CH:25][CH:26]=4)[C:20]3=[O:22])[C:16]=2[O:15][CH2:14][CH2:13]1

Komponenten

6

Edukt 4

HCID 4875Potassium IodideHCID 24408BromineHCID 27355665-(2-Bromoethoxy)-2,3-dihydro-1,4-benzodioxineHCID 24194345Phthalimide potassium salt

Produkt 1

HCID 86754176HCID 86754176, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Replacement of the bromine of the compound obtained in Step A is carried out in dimethylformamide (10 ml) under an argon atmosphere in the presence of potassium phthalimide (1.5 eq.) catalysed by potassium iodide (0.07 eq.). The reaction mixture is stirred and heated at reflux for 3 hours. The residual and resulting salts are removed by filtration; the product is then precipitated in the cold by the addition of water to the filtrate. The solid formed is filtered and then dried in vacuo in the presence of phosphorus pentoxide.

Aufarbeitung

  1. temperatureheated
  2. temperatureat reflux for 3 hours
  3. customThe residual and resulting salts
  4. customare removed by filtration
  5. customthe product is then precipitated in the cold by the addition of water to the filtrate
  6. customThe solid formed
  7. filtrationis filtered
  8. dry with materialdried in vacuo in the presence of phosphorus pentoxide

Quellen und Nachweise

ORD-Eintrag
ord-c0bd2d2f8cdd4fbd9e58c430d403aea5
Quelldatensatz
uspto-grants-1999_07
Patentnummer
US05919814

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