Acetic Anhydride → N-(3,5-dimethoxyphenyl)acetamide

HRID 58123

Reaktionsgleichung

Reaktionsgleichung von HRID 58123
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:11])[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[C:12](OC(=O)C)(=[O:14])[CH3:13]>C1(C)C=CC=CC=1>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([NH:11][C:12](=[O:14])[CH3:13])[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1

Komponenten

4

Edukt 2

HCID 7918Acetic AnhydrideHCID 663013,5-Dimethoxyaniline

Produkt 1

HCID 702039N-(3,5-dimethoxyphenyl)acetamideAusbeute 90.486 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of 3,5-dimethoxy-phenylamine (20 g, 0.131 mol) in toluene (110 mL) was added acetic anhydride (14 g, 0.137 mmol) at room temperature. The resulting mixture was stirred for 18 hours at room temperature. PE (55 mL) was added, the precipitate was filtered and washed with PE (100 mL) to obtain the title compound (24.2 g, yield: 95%). 1H-NMR (400 MHz, CDCl3) δ 2.16 (s, 3H), 3.77 (s, 6H), 6.23 (s, 1H), 6.75 (s, 2H), 7.20 (s, 1H).

Aufarbeitung

  1. additionPE (55 mL) was added
  2. filtrationthe precipitate was filtered
  3. washwashed with PE (100 mL)

Quellen und Nachweise

ORD-Eintrag
ord-7e9f9581dfb944339b040643ad69ba60
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434697B2

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