Acetic Anhydride → N-(3,5-dimethoxyphenyl)acetamide

HRID 58174

Reaktionsgleichung

Reaktionsgleichung von HRID 58174
[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH3:8][O:9][C:10]1[CH:11]=[C:12]([CH:14]=[C:15]([O:17][CH3:18])[CH:16]=1)[NH2:13]>C1(C)C=CC=CC=1.CCCCCC>[CH3:18][O:17][C:15]1[CH:14]=[C:12]([NH:13][C:1](=[O:3])[CH3:2])[CH:11]=[C:10]([O:9][CH3:8])[CH:16]=1

Komponenten

5

Edukt 2

HCID 7918Acetic AnhydrideHCID 663013,5-Dimethoxyaniline

Produkt 1

HCID 702039N-(3,5-dimethoxyphenyl)acetamideAusbeute 98 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1140TolueneLösungsmittelHCID 8058HexaneLösungsmittel

Versuchsvorschrift

Acetic anhydride (6.5 mL) was added slowly to a stirred solution of 3,5-dimethoxy aniline (10 g, 65.359 mmol) in toluene (50 mL) under argon atmosphere at room temperature and resulting reaction mixture was stirred for 15 h. After completion of the reaction, reaction was diluted with Hexane and resulted precipitate was collected by filtration and dried under vacuum to afford the title compound (12.5 g, 98% of yield) as a off-white solid. 1HNMR (CDCl3, 300 MHz): δ 7.38 (s, 1H), 6.75 (d, 2H), 6.23 (s, 1H), 3.76 (s, 6H), 2.15 (s, 3H); MS (ESI): 196.1 [M+H]+.

Aufarbeitung

  1. customresulting
  2. customreaction mixture
  3. customAfter completion of the reaction, reaction
  4. customresulted precipitate
  5. filtrationwas collected by filtration
  6. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-135f662ea86f44bab12e31be80d689b7
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09434697B2

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