Ethyl bromoacetate → ethyl N-(4-fluorophenyl)glycine
Reaktionsgleichung
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:15]1OCCOCCOCCOCCOCCO[CH2:16]1.C([O:35][C:36](=[O:39])[CH2:37]Br)C>C(O)C>[CH2:15]([N:6]([C:5]1[CH:7]=[CH:8][C:2]([F:1])=[CH:3][CH:4]=1)[CH2:37][C:36]([OH:39])=[O:35])[CH3:16]Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
4-Fluoroaniline (5 g), potassium carbonate (3.11 g) and a catalytic amount of 18-Crown-6 were stirred together in 50 ml of ethanol. A solution of ethylbromoacetate (7.52 g) in 25 ml of ethanol was added dropwise and the reaction was heated to reflux.
Aufarbeitung
- temperaturethe reaction was heated to reflux
Quellen und Nachweise
- ORD-Eintrag
- ord-d5edec4fc25d4165a206856d008fcc0a
- Quelldatensatz
- uspto-grants-1993_09
- Patentnummer
- US05246933
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