HCID 12130786, Verbindung → 3-(Pyrimidin-4-yl)aniline

HRID 581966Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 581966
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][N:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.C1COCC1.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][N:11]=2)[CH:7]=[CH:8][CH:9]=1

Komponenten

5

Edukt 1

HCID 12130786HCID 12130786, Verbindung

Produkt 1

HCID 124561713-(Pyrimidin-4-yl)anilineAusbeute 96,1 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittelHCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

To a suspension of (36) (6.3 g, 31 mmol) in a mixture of MeOH (60 ml) and THF (30 ml) was added 5% palladium on activated carbon (300 mg) and the mixture was hydrogenated at ambient pressure for 1 hr. The mixture was filtered and concentrated under reduced pressure. The residue was purified by column-chromatography on silica gel using a mixture of hexane and ethylcetate (3:1) as the eluent to give (37) (5.1 g, 96%).

Aufarbeitung

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by column-chromatography on silica gel using
  4. additiona mixture of hexane and ethylcetate (3:1) as the eluent

Quellen und Nachweise

ORD-Eintrag
ord-83fae483a2e34aa3984ed632684daaf6
Quelldatensatz
uspto-grants-1999_07
Patentnummer
US05922724

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