Water → 3-(3-Fluoro-4-methoxyphenyl)propionic acid

HRID 582208Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 582208
[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][C:12]([O:14]CC)=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].O.[OH-].[K+]>C(O)C.Cl>[F:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

Komponenten

6

Edukt 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 22558762HCID 22558762, Verbindung

Produkt 1

HCID 30179663-(3-Fluoro-4-methoxyphenyl)propionic acidAusbeute 96 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
80 °C

Versuchsvorschrift

To a solution of ethyl 3-(3-fluoro-4-methoxyphenyl)propionate (29.1 g, 129 mmol) in ethanol(50 ml)-water(50 ml) was added potassium hydroxide (9.4 g, 167 mmol) and the mixture was stirred at 80° C. for 1 hour. After cooling, the reaction mixture was poured in diluted hydrochloric acid and the resulting crystals were recovered by filtration and washed with diethyl ether to provide the title compound (yield 24.4 g, 96%).

Aufarbeitung

  1. temperatureAfter cooling
  2. filtrationthe resulting crystals were recovered by filtration
  3. washwashed with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-092c0705c8a040189f7bc12497739e4b
Quelldatensatz
uspto-grants-1999_07
Patentnummer
US05922771

Notizen zur Reaktion

Wird geladen…